Why Is Bisodol Discontinued? - Perú - toda la información del país

Contents

- 0.0.1 Do they still make Bisodol tablets?
0.1 Are Bisodol safe?
- 0.1.1 Is Bisodol still available in the UK?
0.2 Are Bisodol any good?
- 0.2.1 What antacid was banned?
0.3 What is the strongest antacid in the world?
0.4 Can you take too much Bisodol?
0.5 Is it bad to take antacid pills everyday?
0.6 Is it bad to eat too many antacids?
0.7 What is the best antacid for long term use?
0.8 Should I avoid antacids?

1 What is Zantac called now?
- - 1.0.1 Which antacid neutralizes the acid most quickly?
2 Does milk help heartburn?
3 Who manufactures Bisodol?
4 What antacid was recently recalled?
- 4.1 What antacid pills were recalled?
- 4.2 Why are antacids out of stock?

Do they still make Bisodol tablets?

Buy Bisodol Indigestion Relief Online To Buy Bisodol Indigestion Relief Next Day Delivery you are not required to have a prescription, but you will need to complete our free online consultation service.

Are Bisodol safe?

Bisodol Original Indigestion Relief Tablets – Summary of Product Characteristics (SmPC) – (emc) 1. Name of the medicinal product Bisodol Indigestion Relief Tablets 2. Qualitative and quantitative composition Active ingredients:

Sodium Bicarbonate Ph.Eur. Calcium Carbonate Ph.Eur. Magnesium Carbonate Light Ph.Eur.

64mg/tablet
522mg/tablet
68mg/tablet

3. Pharmaceutical form Chewable tablet for oral administration.4. Clinical particulars 4.1 Therapeutic indications For relief of the symptoms of gastric hyperacidity, variously called indigestion, heartburn, dyspepsia and flatulence.4.2 Posology and method of administration

Adults, elderly and children over 12 years:
Suck slowly or chew one or two tablets as required.
Children under 12 years:
Not recommended.

4.3 Contraindications Hypophosphataemia, and avoid in patients with heart failure or renal failure.4.4 Special warnings and precautions for use

If symptoms persist, consult your doctor.
Keep all medicines out of the reach of children.
Not to be taken during the first three months of pregnancy.
Excipient(s)
Sodium
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’.

4.5 Interaction with other medicinal products and other forms of interaction Antacids are known to reduce the absorption of certain medicines including tetracyclines and iron salts.4.6 Pregnancy and lactation Animal studies are insufficient with respect to effects on pregnancy/embryonal/foetal development/parturition and postnatal development.

Caution should be exercised when prescribing to pregnant women.4.7 Effects on ability to drive and use machines 4.8 Undesirable effects Calcium salts can have a constipating effect and magnesium salts can have a laxative effect. The specific mixture of antacids is intended to avoid the lower gastrointestinal effects seen with single antacid preparations.

No side effects associated with sodium bicarbonate except when taken in excess. Rebound hyperacidity may occur with prolonged dosage. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.

Hypermagnesaemia – intravenous administration of calcium salts.
Hypernatraemia – give plenty of salt free fluids.
Hypercalcaemia – remove source of calcium.

5. Pharmacological properties 5.1 Pharmacodynamic properties Sodium bicarbonate, calcium carbonate and magnesium carbonate are antacids. They act by neutralising the hydrochloric acid produced by the stomach and thus reducing gastric and duodenal irritation.5.2 Pharmacokinetic properties Calcium Carbonate Calcium carbonate is converted to calcium chloride by gastric acid.

Some of the calcium is absorbed from the intestines but about 85% is reconverted to insoluble calcium salts, such as the carbonate and is excreted in the faeces.
Magnesium Carbonate Magnesium carbonate reacts with gastric acid to form soluble magnesium chloride and carbon dioxide in the stomach.
Some magnesium is absorbed but is usually excreted rapidly in the urine.

Sodium Bicarbonate Administration of sodium bicarbonate by mouth causes neutralisation of gastric acid with the production of carbon dioxide. Bicarbonate not involved in that reaction is absorbed and in the absence of a deficit of bicarbonate in the plasma, bicarbonate ions are excreted in the urine that is rendered alkaline with an accompanying diuresis.5.3 Preclinical safety data The active ingredients in Bisodol Indigestion Relief Tablets have a well documented safety record.6.

Saccharin Soluble
Maize Starch
Sugar
Calcium Stearate
Peppermint Essential Oil Hanningtons White Diamond (374611E)

6.2 Incompatibilities 6.3 Shelf life

Polypropylene packs: Other packs:

36 months.60 months.

6.4 Special precautions for storage Store at a temperature not exceeding 25°C.6.5 Nature and contents of container

Cellulose over wrapped shell and slide cardboard cartons.
Pack sizes:	12, 30.
250 micron UPVC /20 micron coated aluminium blister packs in cardboard cartons.
Pack sizes:	24, 48.
Cellophane overwrapped carton of 5 rolls of 20 tablets in wax laminated foil with paper labels.
Pack size:	100.
Polypropylene roll holder with a polypropylene cap attached by a banding strip to the 100 tablet carton. Amber glass bottle with black plastic cap.
Pack size:	250.
Rolls of 20 tablets in wax laminated foil with paper label.
Pack size:	20.
Polypropylene container and polypropylene lid.
Pack sizes:	30, 50.
Two rolls of 20 tablets in wax laminated foil packed together in cardboard carton.
Pack size:	40.
Three rolls of 20 tablets in wax laminated foil packed together in cardboard carton.
Pack size:	60.

Not all pack sizes may be marketed.6.6 Special precautions for disposal and other handling 7. Marketing authorisation holder

Teva UK Limited,
Ridings Point,
Whistler Drive,
Castleford,
WF10 5HX,
United Kingdom

8. Marketing authorisation number(s) 9. Date of first authorisation/renewal of the authorisation 29 th January 1987 / 20 th January 2004 10. Date of revision of the text

22/05/2023
Legal Category
GSL

: Bisodol Original Indigestion Relief Tablets – Summary of Product Characteristics (SmPC) – (emc)

Is Bisodol still available in the UK?

This product is available at Sainsburys, Asda, Amazon.co.uk, Superdrug.

Are Bisodol any good?

These are effective and taste pleasant. They work. They work on reflux. These tablets are great for any stomach acid related issues.

What antacid was banned?

FDA Advises Consumers, Patients and Health Care Professionals After New FDA Studies Show Risk to Public Health – For Immediate Release: April 01, 2020 Español The U.S. Food and Drug Administration today announced it is requesting manufacturers withdraw all prescription and over-the-counter (OTC) ranitidine drugs from the market immediately.

This is the latest step in an ongoing investigation of a contaminant known as N-Nitrosodimethylamine (NDMA) in ranitidine medications (commonly known by the brand name Zantac).
The agency has determined that the impurity in some ranitidine products increases over time and when stored at higher than room temperatures and may result in consumer exposure to unacceptable levels of this impurity.

As a result of this immediate market withdrawal request, ranitidine products will not be available for new or existing prescriptions or OTC use in the U.S. “The FDA is committed to ensuring that the medicines Americans take are safe and effective. We make every effort to investigate potential health risks and provide our recommendations to the public based on the best available science.

We didn’t observe unacceptable levels of NDMA in many of the samples that we tested.
However, since we don’t know how or for how long the product might have been stored, we decided that it should not be available to consumers and patients unless its quality can be assured,” said Janet Woodcock, M.D., director of the FDA’s Center for Drug Evaluation and Research.

“The FDA will continue our efforts to ensure impurities in other drugs do not exceed acceptable limits so that patients can continue taking medicines without concern.” NDMA is a probable human carcinogen (a substance that could cause cancer). In the summer of 2019, the FDA became aware of independent laboratory testing that found NDMA in ranitidine.

Low levels of NDMA are commonly ingested in the diet, for example NDMA is present in foods and in water. These low levels would not be expected to lead to an increase in the risk of cancer. However, sustained higher levels of exposure may increase the risk of cancer in humans. The FDA conducted thorough laboratory tests and found NDMA in ranitidine at low levels.

At the time, the agency did not have enough scientific evidence to recommend whether individuals should continue or stop taking ranitidine medicines, and continued its investigation and warned the public in September 2019 of the potential risks and to consider alternative OTC and prescription treatments.

New FDA testing and evaluation prompted by information from third-party laboratories confirmed that NDMA levels increase in ranitidine even under normal storage conditions, and NDMA has been found to increase significantly in samples stored at higher temperatures, including temperatures the product may be exposed to during distribution and handling by consumers.

The testing also showed that the older a ranitidine product is, or the longer the length of time since it was manufactured, the greater the level of NDMA. These conditions may raise the level of NDMA in the ranitidine product above the acceptable daily intake limit.

With today’s announcement, the FDA is sending letters to all manufacturers of ranitidine requesting they withdraw their products from the market.
The FDA is also advising consumers taking OTC ranitidine to stop taking any tablets or liquid they currently have, dispose of them properly and not buy more; for those who wish to continue treating their condition, they should consider using other approved OTC products.

Patients taking prescription ranitidine should speak with their health care professional about other treatment options before stopping the medicine, as there are multiple drugs approved for the same or similar uses as ranitidine that do not carry the same risks from NDMA.

To date, the FDA’s testing has not found NDMA in famotidine (Pepcid), cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid) or omeprazole (Prilosec). In light of the current COVID-19 pandemic, the FDA recommends patients and consumers not take their medicines to a drug take-back location but follow the specific disposal instructions in the medication guide or package insert or follow the agency’s recommended steps, which include ways to safely dispose of these medications at home.

The FDA continues its ongoing review, surveillance, compliance and pharmaceutical quality efforts across every product area, and will continue to work with drug manufacturers to ensure safe, effective and high-quality drugs for the American public. The FDA encourages health care professionals and patients to report adverse reactions or quality problems with any human drugs to the agency’s MedWatch Adverse Event Reporting program:

Complete and submit the report online at www.fda.gov/medwatch/report.htm ; or Download and complete the form, then submit it via fax at 1-800-FDA-0178.

The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices.

What is the strongest antacid in the world?

Calcium Carbonate – Calcium Carbonate (chalk) is the most potent usable antacid. It can completely neutralize stomach acid.

Can you take too much Bisodol?

If you take more Bisodol Indigestion Relief Tablets than you should It is unlikely that they will cause you any harm. However, you may experience constipation, diarrhoea or feel bloated. Consult your doctor if these symptoms do not go away.

Is it bad to take antacid pills everyday?

What are the side effects of an antacid? – Complications after taking an antacid mostly affect infants or people over the age of 65. Side effects could include:

Constipation or diarrhea. Gas (flatulence). Headache. Nausea and vomiting. Stomach cramps or pain in the abdomen.

Serious side effects could include:

Acid rebound: Antacids cause your body to produce more acid, which worsens symptoms. Neurotoxicity: An antacid changes the function of your nervous system. Microcytic anemia : Iron deficiency. Osteopenia : Weakened bones. Hypercalcemia : Too much calcium in your blood.

Don’t take antacids frequently. If you experience symptoms of heartburn or indigestion daily, reach out to your healthcare provider to look into the cause of your symptoms.

Is it bad to eat too many antacids?

Side effects from misuse – Many of the side effects of antacids come from not taking them as directed. Many antacids — including Maalox, Mylanta, Rolaids and Tums — contain calcium. If you take too much or take them for longer than directed, you could get an overdose of calcium. Too much calcium can cause:

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nausea vomiting mental status changes kidney stones

Excess calcium can also lead to alkalosis, In this condition, your body doesn’t make enough acid to function properly. If you feel like you need to use a lot of an antacid for relief, that might be a sign of another condition. If you’ve taken an antacid according to the directions and haven’t gotten relief, talk to your doctor.

Antacids can interfere with the function of other drugs.
If you take other medications, check with your doctor or pharmacist before using antacids.
Some antacids, such as Alka-Seltzer, contain aspirin.
The Food and Drug Administration issued a safety alert about this type of antacid in June 2016.
This alert was issued because of reports of serious bleeding related to aspirin-containing antacids.

If you take another medication that increases your risk of bleeding, such as an anticoagulant or antiplatelet drug, you shouldn’t take these antacids. Be sure to talk to your doctor before taking aspirin-containing antacids if you:

have a history of stomach ulcers or bleeding disorders are older than 60 years olddrink three or more alcoholic drinks per day

If you have acid reflux or other symptoms caused by stomach acidity, get to know your OTC medications. Antacids neutralize the acid that your stomach makes. This can make you more comfortable. On the other hand, H2 receptor blockers and PPIs can block your stomach from making too much acid. This can allow the damage in your stomach and esophagus to heal. Ask your doctor which is better for you.

Does Lidl sell antacid?

Package/Label Principal Display Panel –

NDC 71141-144-32
*Compare to the active ingredient in Ultra Strength Tums ®
ULTRA STRENGTH
Antacid
CALCIUM CARBONATE TABLETS
assorted fruit flavors
72 tablets
1000 mg each
K
PAREVE
GLUTEN- FREE
DISTRIBUTED BY
Lidl US LLC
3500 S. Clark Street
Arlington, VA 22202
QUESTIONS?
1-844-656-5151

www.Lidl.com *This product is not manufactured or distributed by GlaxoSmithKline LLC, owner of the registered trademark, Ultra StrengthTums®.

Revised: 8/2022
Lidl US LLC

: LIDL Ultra Strength Antacid Calcium Carbonate Chewable Tablets

Why are antacids out of stock?

Copy the code below to embed the WBUR audio player on your site – Resume Antacid tablets. (Getty Images) People suffering from “pandemic stomach” are buying up Tums, Pepcid and other over-the-counter antacids like they’re the new toilet paper. Wegmans started limiting shoppers to just two packets to prevent hoarding. But the problem isn’t always the heartburn associated with spicy or acidic foods.

If reflux goes on for a long time, Dr.
Thomas Carroll of Brigham and Women’s Hospital in Boston recommends seeing a doctor.
I definitely am a believer that stress plays a role in reflux,” he says.
And it may not be that it actually increases the amount of reflux that people get, but rather makes us more sensitive to the reflux we already have.” With gastroesophageal reflux disease, or GERD, stomach acids back up as far as the esophagus.

There’s also another condition called laryngopharyngeal acid reflux disease, or LPR, where the stomach juice goes past the esophagus and into the throat, Carroll says. With LPR, the problem could be caused by a stomach enzyme such as pepsin. Pepsin can stay in the throat for hours, so eating or drinking acidic foods like coffee, dark chocolate or wine can reactivate the enzyme and cause inflammation in the tissue, he says.

The most common symptoms of LPR are cough, throat clearing and postnasal drip, he says, rather than heartburn and regurgitation. “I find the most difficult cough patients to be those that have been treated for everything under the sun except for the non-acidic reflux,” he says. People with LPR more commonly show daytime symptoms, while GERD often causes people to wake up with a cough from laying down flat in bed, he says.

Carroll recommends that people with any reflux issue sleep on an incline, but don’t rely on pillows that one can easily slide off of. He also suggests refraining from eating close to bedtime and losing a bit of extra weight to alleviate abdominal pressure.

Antacids like Prilosec help about two-thirds of patients, he says, but some people don’t respond to them. In recent years, doctors have switched to recommending medications with alginates. Made from brown seaweed, alginates form a raft on top of a patient’s stomach contents so the liquid can’t travel up to the esophagus or throat, he says.

Gaviscon heartburn relief tablets and a new product made in California called Reflux Gourmet contain alginates. People can’t buy a more effective Canadian version of Gaviscon in U.S. pharmacies yet, but it’s available on Amazon, he says. During the pandemic, Carroll says he’s seen spikes in people coming into his office with reflux issues.

“Those people were the people who are losing jobs, having to stay home all day, being stressed out by the pandemic,” he says. “We’ve seen so many more cases of what we would suspect being LPR than we did before the pandemic.” Robin Young produced and edited this interview for broadcast with Jill Ryan,

Allison Hagan adapted it for the web. This segment aired on December 30, 2020. Robin Young Co-Host, Here & Now Robin Young brings more than 25 years of broadcast experience to her role as host of Here & Now. More Allison Hagan Digital Producer, Here & Now Allison Hagan is a digital producer for Here & Now. More

Is Bisodol good for heartburn?

Bisodol® indigestion relief tablets – For adults and children over 12 years. Suck or chew one or two tablets as required. Not recommended for children under 12 years. If symptoms persist, please consult your doctor. If you are pregnant talk to your doctor before using this medicine. Always read the package leaflet.

What is the best antacid for long term use?

Omeprazole: Best OTC Heartburn Medication – Omeprazole, commonly known as Prilosec, is a PPI that reduces the quantity of food-digesting acid made by the cells within the lining of your stomach. In fact, Prilosec was one of the first and strongest PPIs created to combat acid reflux.

According to Dr. Ghouri, Prilosec OTC “is usually sufficient in controlling symptoms in a majority of cases” and has been the #1 Doctor Recommended frequent heartburn relief medicine for 14 years. There are various benefits to using Prilosec OTC, most notably the ease of the dosing schedule and the effectiveness in lowering frequent piques of heartburn in individuals.

When taking Prilosec OTC, you only have to take one pill per day for 14 days. Although it may take between one to four days to experience the full effect, Prilosec OTC begins to work, and individuals notice relief on the first day of treatment. After the fourteenth day, acid production should grow to be controlled consistently.

Is Gaviscon better than antacid tablets?

References – 1. Camilleri M, Dubois D, Coulie B, et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.2005; 3 (6):543–52.2.

Fletcher J, Wirz A, Young J, Vallance R, McColl KE.
Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal.
Gastroenterology.2001; 121 (4):775–83.3.
Ahrilas PJ, McColl K, Fox M, et al.
The acid pocket: a target for treatment in reflux disease? The American journal of gastroenterology.2013; 108 (7):1058–64.4.

Clarke AT, Wirz AA, Seenan JP, Manning JJ, Gillen D, McColl KE. Paradox of gastric cardia: it becomes more acidic following meals while the rest of stomach becomes less acidic. Gut.2009; 58 (7):904–9.5. Beaumont H, Bennink RJ, de Jong J, Boeckxstaens GE.

The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD.
Gut.2010; 59 (4):441–51.6.
Pandolfino JE, Zhang Q, Ghosh SK, Post J, Kwiatek M, Kahrilas PJ.
Acidity surrounding the squamocolumnar junction in GERD patients: “acid pocket” versus “acid film” The American journal of gastroenterology.2007; 102 (12):2633–41.7.

Kahrilas PJ, Shaheen NJ, Vaezi MF, et al. American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease. Gastroenterology.2008; 135 (4):1383–1391.1391 e1–5.8. Rohof WO, Bennink RJ, Boeckxstaens GE.

Proton Pump Inhibitors Reduce the Size and Acidity of the Acid Pocket in the Stomach. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.2014 Epub ahead of print.9. Vo L, Simonian HP, Doma S, Fisher RS, Parkman HP. The effect of rabeprazole on regional gastric acidity and the postprandial cardia/gastro-oesophageal junction acid layer in normal subjects: a randomized, double-blind, placebo-controlled study.

Alimentary pharmacology & therapeutics.2005; 21 (11):1321–30.10. Rohof WO, Bennink RJ, Smout AJ, Thomas E, Boeckxstaens GE. An alginate-antacid formulation localizes to the acid pocket to reduce acid reflux in patients with gastroesophageal reflux disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.2013; 11 (12):1585–91. quiz e90.11. Pandolfino JE, Ghosh SK, Zhang Q, Jarosz A, Shah N, Kahrilas PJ. Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers.

American journal of physiology Gastrointestinal and liver physiology.2006; 290 (5):G1033–40.12. Roman S, Zerbib F, Belhocine K, des Varannes SB, Mion F. High resolution manometry to detect transient lower oesophageal sphincter relaxations: diagnostic accuracy compared with perfused-sleeve manometry, and the definition of new detection criteria.

Alimentary pharmacology & therapeutics.2011; 34 (3):384–93.13.
Cannon WB.
The Movements of the stomach, studied by means of the Rontgen Rays.
Boston Soc Med Sci.1898; 2 :59–66.14.
Wiatek MA, Roman S, Fareeduddin A, Pandolfino JE, Kahrilas PJ.
An alginate-antacid formulation (Gaviscon Double Action Liquid) can eliminate or displace the postprandial ‘acid pocket’ in symptomatic GERD patients.

Alimentary pharmacology & therapeutics.2011; 34 (1):59–66.15. Sweis R, Kaufman E, Anggiansah A, et al. Post-prandial reflux suppression by a raft-forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH-impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, double-blind study in reflux patients.

Alimentary pharmacology & therapeutics.2013; 37 (11):1093–102.16. Hampson FC, Farndale A, Strugala V, Sykes J, Jolliffe IG, Dettmar PW. Alginate rafts and their characterisation. International journal of pharmaceutics.2005; 294 (1–2):137–47.17. Zentilin P, Dulbecco P, Savarino E, et al. An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry.

Alimentary pharmacology & therapeutics.2005; 21 (1):29–34.18. Thomas E, Wade A, Crawford G, Jenner B, Levinson N, Wilkinson J. Randomised clinical trial: relief of upper gastrointestinal symptoms by an acid pocket-targeting alginate-antacid (Gaviscon Double Action) – a double-blind, placebo-controlled, pilot study in gastro-oesophageal reflux disease.

What is the best antacid after eating?

Antacids, such as TUMS, Rolaids, and Maalox, neutralize the acid that has already been produced in your stomach. They act fast, usually within 5 minutes, but they only last for 30 to 60 minutes, says Dr. Zhou, so they are best for immediate relief when you’re experiencing mild heartburn after a meal.

Why was Gaviscon taken off the market?

What to do about the heartburn medication recall – Harvard Health Some drugs that contain ranitidine (best known as Zantac) have been found by the FDA to have unacceptable amounts of N-nitrosodimethylamine (NDMA), a possible cancer-causing chemical (which also triggered recalls of certain lots of the blood pressure drugs called angiotensin-receptor blockers).

On April 1, 2020, the FDA requested that all forms of ranitidine (Zantac, generic versions), including prescription and over-the-counter products, be removed from the market. They may contain unacceptable levels of a potential cancer-causing substance known as NDMA, or N-Nitrosodimethylamine. In some samples tested by the FDA, the impurity appears to increase over time, especially when stored at higher temperatures.

So far, tests of other acid blockers do not show this potential increased cancer risk. People using over-the-counter ranitidine should stop taking it and consider a different acid blocking therapy, such as famotidine (Pepcid) or cimetidine (Tagamet). They’re all in a class of medications known as H2 blockers, which block a chemical that signals the stomach to produce acid.

“They’re fairly interchangeable, working equally well for most people,” says Dr. Kyle Staller, a gastroenterologist with Harvard-affiliated Massachusetts General Hospital. Stronger heartburn medications include a class of drugs called proton-pump inhibitors, or PPIs, such as over-the-counter lansoprazole (Prevacid) or omeprazole (Prilosec).

Long-term use of PPIs has been linked to reduced blood levels of vitamin B 12 and magnesium. While the possibility of other health risks has been raised in the past, Dr. Staller says the data supporting those risks aren’t conclusive. There’s no evidence of risks from long-term use of H2 blockers.

For those taking prescription ranitidine, they should contact their doctor for advice.
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: What to do about the heartburn medication recall – Harvard Health

Should I avoid antacids?

Side effects of antacids – Antacids do not usually have many side effects if they’re only taken occasionally and at the recommended dose. But sometimes they can cause:

diarrhoea or constipation flatulence (wind)stomach crampsfeeling sick or vomiting

These should pass once you stop taking the medicine. Speak to a pharmacist or a GP if side effects do not improve or are troublesome. You may need to switch to another medicine.

What is Zantac called now?

Recently, Zantac relaunched with a new name and a different ingredient — Zantac 360 (famotidine). Famotidine doesn’t have the same cancer risk as ranitidine, making it a safer option. Famotidine is available over-the-counter as a lower-cost generic.

Which antacid neutralizes the acid most quickly?

Onset of acid-neutralizing action of a calcium/magnesium carbonate-based antacid using an artificial stomach model: an in vitro evaluation Received 2020 Dec 6; Accepted 2021 Feb 23. © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit, The Creative Commons Public Domain Dedication waiver () applies to the data made available in this article, unless otherwise stated in a credit line to the data. Calcium carbonate antacids are potent over-the-counter antacids, made more effective by adding magnesium carbonate (as in Rennie, Bayer).

However, published studies on their onset of action are scarce. Therefore, we carried out an in vitro study comparing Rennie and placebo under simulated conditions of the human stomach (artificial stomach model) to reconfirm the onset of action of Rennie. The validated Simulator of the Human Intestinal Microbial Ecosystem apparatus (SHIME, ProDigest, Belgium) was used, comprising five reactors simulating different parts of the human gastrointestinal tract.

Both Rennie and placebo were dosed at two tablets per incubation over six independent, 2-h stomach incubations each. Primary objectives: to evaluate the time required to achieve pH 3.0, 3.5, 4.0 and 4.5, as well as the maximum pH reached. Secondary objective: to evaluate pepsin activity over the entire 2-h gastric incubation.

After addition of Rennie, the gastric medium reached a pH of 3.0 within 40 s. The maximum pH of 5.24 was maintained for almost 10 min. In contrast, the maximum pH with placebo was 1.28 during the entire gastric simulation. Furthermore, Rennie strongly reduced the activity of mucosa-damaging pepsin during the period of increased pH.

With placebo, the lower pH resulted in consistently high loads of digested peptides, reflecting the high cumulative and instantaneous pepsin activity. New data is a critical component in informed decision making. Our data confirm the high efficacy and fast onset of acid-neutralizing action of Rennie, which begins to work within seconds.

Eywords: Acid-neutralizing action, Antacid, Calcium carbonate, Magnesium carbonate, Pepsin activity Antacids have been widely used for many years for the symptomatic treatment of gastroesophageal reflux disease and mild, non-ulcer dyspepsia, Calcium carbonate-based antacids are one of the most potent over-the-counter antacids, known to have a rapid, long-lasting, and effective neutralizing action that is increased by the addition of magnesium carbonate, as in Rennie ® (Bayer).

In the lower esophagus or in the stomach, calcium and magnesium carbonate react with the hydrochloric acid to form water and soluble mineral salts. However, although Rennie is a well-established antacid that has been on the market for over 85 years, published studies on the onset of action of calcium carbonate are scarce.

The scientific data demonstrating its onset of action were generated some time ago and remain unpublished.
Much has changed since then, and it is time to reconfirm the onset of action for Rennie.
Therefore, we carried out an in vitro study comparing Rennie and placebo under simulated conditions of the human stomach.

The SHIME ® apparatus (Simulator of the Human Intestinal Microbial Ecosystem, ProDigest, Belgium) was used, which mimics the physiological and microbiological conditions representative of the human gastrointestinal tract (GIT). SHIME has been in extensive use for more than 25 years and has been validated using in vivo parameters.

The system comprises a succession of five reactors simulating different parts of the human GIT (Fig.), The first two reactors simulate different steps in food uptake and digestion (stomach, small intestine), while the last three compartments simulate the ascending, transverse, and descending colon. Overview of the SHIME (top) and adapted SHIME (bottom) apparatus.

The adapted SHIME used one reactor in a sequential setup to simulate the stomach under fasted conditions (red rectangle). The SHIME apparatus (top right) represents the gastrointestinal tract of adult humans and incorporates peristaltic pumps (for automated administration of secretions, acid or base), pH controllers (to register online pH), heating elements (to maintain temperature at 37 °C), and magnetic stirrers (to homogenize contents).

The first two reactors use the ‘fill-and-draw’ principle to simulate different steps in food uptake and digestion, with peristaltic pumps adding a defined amount of SHIME feed and gastric secretions (pepsin and HCl) to the stomach compartment and pancreatic/bile liquid to the small intestinal compartment.

Peristaltic pumps also ensure emptying of the respective reactors after specified intervals. The last three compartments—continuously stirred reactors with constant volume and pH control—simulate the ascending, transverse, and descending colon. Retention time and pH of the different vessels are chosen to resemble in vivo conditions in the different parts of the gastrointestinal tract.

The TWINSHIME setup (top left) consists of two SHIME systems in parallel.
SHIME, Simulator of the Human Intestinal Microbial Ecosystem (ProDigest, Belgium).
Image provided courtesy of ProDigest Our results should be of interest and relevance to healthcare providers and consumers.
New data is a critical component in informed decision making and should be reassuring to those who have been recommending Rennie or selecting it for daily use based on its high efficacy and fast onset of action.

The antacid tested was Rennie Spearmint Chewable tablets (Bayer) (sugar-free), containing calcium carbonate (680 mg) and magnesium carbonate (80 mg) as active ingredients. The antacid was tested against placebo, both dosed at two tablets per incubation over six independent, 2-h stomach incubations each.

The endpoints of the gastric incubations are outlined in Table,
The primary objectives were to evaluate the time required to achieve a pH of 3.0, 3.5, 4.0 and 4.5, as well as the maximum pH and duration of maximum pH, when the antacid was added to the simulated gastric environment.
A secondary objective was to evaluate the pepsin activity over the entire 2-h gastric incubation using two methods: (1) cumulative pepsin activity, assessed via protein degradation over time; (2) instantaneous pepsin activity, assessed using a mathematical model constructed after a pH-based pre-test.

Gastric incubation endpoints after administration of calcium/magnesium carbonate-based antacid (maximum recommended single dose) or placebo


pH profile	Pepsin activity
pH measured every 15 s within the first 5 min; thereafter, every 5 min until the end of the 2-h incubation	1) Cumulative activity: indirect measurement of digested amount of reference protein (BSA) after 0, 2.5, 5, 10, 15, 30, 45, 60, 90, 120 min a
Time to reach pH 3.0, 3.5, 4.0, 4.5 Maximum pH and duration of highest pH value (-0.1 pH unit)	2) Instantaneous activity: mathematical model, where pepsin activity was measured every 0.25 pH units from pH 1–7, using the same measurement of digested BSA as in 1) b

To this purpose, we employed a standardized protocol using an adapted SHIME system that allows the conditions within one reactor to be modified to focus on one or more gastrointestinal region of interest (Fig.). By focusing on just one gastrointestinal compartment, multiple replicates could be run in parallel. In our case, the focus was on simulation of the stomach under fasted conditions. Protocols based on the InfoGest consensus method, and a standardized protocol from literature to evaluate acid-neutralizing profiles of actives were used to ensure that simulation of the upper GIT was performed under the most representative conditions. Briefly, a number of mucin-covered microcosms (simulating the mucus layer of the intestinal surface) with 100 mL of 0.1 N HCl (= total of 10 mmol H + , pH 1.0) were added to each stomach compartment containing relevant gastric compounds (mucins and salts such as KCl and NaCl) and the reference protein BSA (bovine serum albumin). At the start of the 2-h gastric incubation, the antacid and placebo were administered at a maximum single recommended dose. Thereafter, gastric acid secretion was simulated by pumping 0.1 N HCl into the stomach at a rate of 3 mL/min while gastric emptying was simulated by emptying the stomach at 1.5 mL/min, representing a slower emptying relative to the acid secretion rate. The content of each reactor was mixed continuously by means of magnetic stirring. The pH of the gastric environment began at 1.0 and increased with addition of both antacid and placebo (Fig.). With antacid, the pH increased to > 3.0 within 40 s, and to > 4.5 at 1 min 54 s (Table ). Overall, a pH > 3.0 was maintained for 56 min 1 s ± 1 min 9 s. The maximum pH of 5.24 was reached within 10 min and maintained for 9 min 56 s. Between 30 min and 1 h, the pH began to gradually decline due to the continuous influx of HCl. Average gastric pH profile after adding calcium/magnesium carbonate-based antacid or placebo. Average pH profile of six independent repetitions of gastric incubations after adding the calcium/magnesium carbonate-based antacid (Rennie Spearmint, Bayer) or placebo to the gastric medium. a First 5 min of incubation; b changes throughout the entire incubation period (2 h). Throughout the entire incubation, 0.1 N HCl was supplied at 3 mL/min, while gastric emptying was mimicked by removing the content at 1.5 mL/min Acid-neutralizing activity of the calcium/magnesium carbonate-based antacid versus placebo (n = 6)


pH parameter	Placebo	Antacid
Time to reach pH:
3.0	–	00:00:40 ± 00:00:02
3.5	–	00:00:53 ± 00:00:02
4.0	–	00:01:13 ± 00:00:04
4.5	–	00:01:54 ± 00:00:12
Maximum pH	1.28 ± 0.10	5.24 ± 0.07
Duration of maximum pH	00:13:05 ± 00:07:20	00:09:56 ± 00:00:44

In contrast, the pH did not reach pH 3.0 during the entire gastric simulation with placebo (max. pH 1.28). With the antacid, there was a decrease in both cumulative and instantaneous pepsin activity (Fig.) that was in line with the increase in pH values within the first 5 min and over the longer term (2 h).

With placebo, the lower pH resulted in consistently high loads of digested peptides, reflecting the high cumulative and instantaneous pepsin activity (maximal peptide level between 15 and 30 min of incubation).
Average a cumulative and b instantaneous increase in gastric pepsin activity with antacid or placebo.

The graphs reflect the concentration of digested peptide/protein fractions due to the action of pepsin on a reference protein (bovine serum albumin) during antacid or placebo incubations (n = 6) (absorbance values at 280 nm). Graphs on the left focus on the first 5 min of incubation, while those on the right show the changes throughout the entire incubation period After 30 min (cumulative activity) and 45 min (instantaneous activity) of incubation, the declining pH values with antacid resulted in increased digested peptide fractions and thus increased pepsin activity, with maximum pepsin activity reached after 1 h of incubation.

It should be noted that after 1 h of incubation, pepsin activity was higher for the antacid than placebo because the pH of the antacid incubations was closer to the optimum pH of pepsin activity (around 1.75).
Due to the constant influx of gastric secretions at pH = 1.0, the pH in the placebo incubation had already decreased to below this optimum value.

Antacids are widely used in the treatment of mild-to-moderate symptoms of gastroesophageal disease such as heartburn, which occurs when acid travels up from the stomach to cause a burning sensation in the throat. Calcium carbonate has been used for decades to neutralize the acid and provide relief from heartburn,

However, published data for the onset of action of the calcium/magnesium carbonate-based antacid Rennie is lacking, and needed to be addressed to support confidence in its use.
Our in vitro study used a validated stomach model that confirmed the antacid has fast-acting and strong acid-neutralizing properties—a meaningful increase in pH was rapidly achieved within 40 s and maintained for almost one hour.

This data is novel, as it was previously understood that the acid neutralization provided by Rennie began after 2 min; in fact, Rennie begins to work much faster than that, within seconds. Pepsin is required to initiate the digestion of proteins, and a pH 1–2 is required for its activity; activity is limited at around pH 3.5–5,

Gastric juices normally protect the gastric mucosa, but it may be susceptible to digestion at low pH values. Thus, the enzyme is also a known mucosa-damaging factor in heartburn and regurgitation, and its activity should be limited. After administration of Rennie in our study, the activity of pepsin was reduced both within the first 5 min and over the longer term (2 h).

In vitro assessment has indicated that both calcium carbonate and magnesium carbonate have high anti-peptic activity (82% and 82%, respectively), Current technological advancements have allowed our experiment to be performed in the least intrusive manner.

Repeating a clinical study seemed ethically unjustified, since new data would not be generated. Yet a simple in vitro acid neutralization test would not be relevant from a clinical practice perspective. We believe that a validated artificial stomach model was the best choice and a strength of the study, offering scientifically rigorous methodology in an environment closely mimicking human physiology.

Future experiments comparing Rennie against other common antacids may be helpful to confirm its fast onset of acid neutralization. The calcium/magnesium carbonate-based antacid Rennie has strong acid-neutralizing effects. In this artificial stomach model, which mimics the physiological and microbiological conditions of the human GIT, the gastric medium reached a pH of 3.0 within 40 s and was maintained for almost 1 h.

BSA	Bovine serum albumin
GIT	Gastrointestinal tract
SHIME	Simulator of the Human Intestinal Microbial Ecosystem
TCA	Trichloroacetic acid

MV provided the concept for the manuscript and all the data and reviewed the manuscript at every stage. DN drafted and edited the manuscript. Both authors read and approved the final manuscript. The study was funded by Bayer Consumer Care AG. The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data, which were done by ProDigest.

The manuscript was written by Bayer and a professional medical writer funded by Bayer. The datasets used and/or analyzed during the current study are available from the corresponding authors on reasonable request. Ethics approval and consent to participate Not applicable. Consent for publication Not applicable.

Competing interests MV is an employee of Bayer Consumer Care AG. DN is a professional medical writer whose services in writing the manuscript were funded by Bayer Consumer Care AG. Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.1.

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Does milk help heartburn?

Milk – Does milk help with heartburn? “Milk is often thought to relieve heartburn,” says Gupta. “But you have to keep in mind that milk comes in different varieties — whole milk with the full amount of fat, 2% fat, and skim or nonfat milk. The fat in milk can aggravate acid reflux.

Who manufactures Bisodol?

Bisodol Indigestion Relief Tablets are available in packs of 20, 30, 60 and 100 tablets. Not all pack sizes may be marketed. Manufacturer Brunel Healthcare Manufacturing Ltd, Swadlincote, Derbyshire, DE11 0BB, United Kingdom.

What antacid was recently recalled?

The Food and Drug Administration has recalled several more lots of heartburn medications, including more generic versions of Zantac, that have been found to contain trace amounts of a substance that may be linked to cancer. The World Health Organization has classified that substance, N-Nitrosodimethylamine (NDMA), as a “probable human carcinogen.” The FDA said that Denton Pharma Inc. The recalled batches include certain lots of ranitidine tablets in 150 milligram and 300 mg strengths. Appco Pharma has also recalled batches of ranitidine because of the potential presence of NDMA. The recalled lots have an expiration date of April or May 2021.

None of the recalled lots has been associated with any injuries or adverse events. On Wednesday, the FDA also announced that the drug company Mylan has recalled three lots of another antacid, nizatidine, which were also found to contain trace amounts of NDMA. Those capsules, in 150mg and 300mg strengths, were manufactured by Solara Active Pharma Sciences Limited.

Nizatidine is used for short-term treatment of stomach ulcers as well as heartburn caused by gastroesophageal reflux disease, the FDA wrote on its website, Recalled batches include nizatidine capsules sold in bottles of 60 with an expiration date of May, as well as nizatidine capsules sold in bottles of 30 with an expiration date of January.

The FDA said it has not received any reports of injuries associated with taking the medications.
It’s unclear whether such trace amounts of the carcinogens would cause harm when taken as directed.
FDA testing of recalled ranitidine detected NDMA levels similar to the levels found in grilled and smoked meats.

Federal regulators said other heartburn medications, such as famotidine (Pepcid), cimetidine (Tagamet), esomeprazole (Nexium), lansoprazole (Prevacid) and omeprazole (Prilosec) have not tested positive for signs of NDMA. Follow NBC HEALTH on Twitter & Facebook, Erika Edwards Erika Edwards is a health and medical news writer and reporter for NBC News and “TODAY.”

What antacid pills were recalled?

– Some drugs that contain ranitidine (best known as Zantac) have been found by the FDA to have unacceptable amounts of N-nitrosodimethylamine (NDMA), a possible cancer-causing chemical (which also triggered recalls of certain lots of the blood pressure drugs called angiotensin-receptor blockers).

On April 1, 2020, the FDA requested that all forms of ranitidine (Zantac, generic versions), including prescription and over-the-counter products, be removed from the market.
They may contain unacceptable levels of a potential cancer-causing substance known as NDMA, or N-Nitrosodimethylamine.
In some samples tested by the FDA, the impurity appears to increase over time, especially when stored at higher temperatures.

They’re fairly interchangeable, working equally well for most people,” says Dr.
Yle Staller, a gastroenterologist with Harvard-affiliated Massachusetts General Hospital.
Stronger heartburn medications include a class of drugs called proton-pump inhibitors, or PPIs, such as over-the-counter lansoprazole (Prevacid) or omeprazole (Prilosec).

Why are antacids out of stock?

If reflux goes on for a long time, Dr. Thomas Carroll of Brigham and Women’s Hospital in Boston recommends seeing a doctor. “I definitely am a believer that stress plays a role in reflux,” he says. “And it may not be that it actually increases the amount of reflux that people get, but rather makes us more sensitive to the reflux we already have.” With gastroesophageal reflux disease, or GERD, stomach acids back up as far as the esophagus.

The most common symptoms of LPR are cough, throat clearing and postnasal drip, he says, rather than heartburn and regurgitation.
I find the most difficult cough patients to be those that have been treated for everything under the sun except for the non-acidic reflux,” he says.
People with LPR more commonly show daytime symptoms, while GERD often causes people to wake up with a cough from laying down flat in bed, he says.

Antacids like Prilosec help about two-thirds of patients, he says, but some people don’t respond to them.
In recent years, doctors have switched to recommending medications with alginates.
Made from brown seaweed, alginates form a raft on top of a patient’s stomach contents so the liquid can’t travel up to the esophagus or throat, he says.

“Those people were the people who are losing jobs, having to stay home all day, being stressed out by the pandemic,” he says. “We’ve seen so many more cases of what we would suspect being LPR than we did before the pandemic.” Robin Young produced and edited this interview for broadcast with Jill Ryan,